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Further evidence of hemodynamic benefit is suggested by a recent mediation analysis from EMPA-REG showing that markers of plasma volume such as hematocrit and hemoglobin were important markers associated with reduction in cardiovascular mortality observed with SGLT2i use (10,78)
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The results that d-allulose moderately increased insulin release only at 15 min prompted us to explore possible additional mechanisms for the glycemic action of d-allulose
Human clinical trials are limited but ongoing
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