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Chronic ICV administration of oxyntomodulin, a GLP-1R agonist, in mice decreased body weight despite having no significant effects on food intake (Lockie et al., 2012)
Other Benefits Because GLP-1 agonists help reduce body weight and lower glucose levels, they can also lower blood pressure and alleviate chronic inflammation, conditions that contribute to the development of chronic cardiovascular disease
Some common side effects encompass nausea, vomiting, diarrhea, abdominal pain, and decreased appetite
doi:10.1073/pnas.1817984116
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