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The analysis is based on results from the STEP 1 trial, published in 2021 in the New England Journal of Medicine , which showed the 2.4 mg dosage of semaglutide approved by the FDA for the treatment of obesity reduced body weight by an average of 14.9% along with reductions in several cardiovascular risk factors such as blood pressure and lipids
Here's why and how to make sure you're getting enough
However, since all other GLP-1 options are injections, Rybelsus is a good choice for those who have trouble with self-injections
JAMA Health Forum 6 , e245015 (2025)
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