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Gastro-intestinal symptoms score was assessed based on the score of Adam and collaborators 16 as follows: Parents were asked to indicate whether their children had experienced specific GI symptoms nausea, vomiting, bloating, abdominal cramps, early satiety, eructation or heartburn, loss of appetite, retrosternal discomfort and epigastric pain or abdominal pain over the past month

Adipocytes lacking Bmal1 had reduced expression of genes involved in fatty acid metabolism, lipid biosynthesis and fat cell differentiation (Fig