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The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
53 Furthermore, elevated cholesterol levels in the microenvironment stimulate the expression of immune checkpoints, including PD-1, 2B4, TIM-3, and LAG-3, in T cells, driving T-cell exhaustion via the activation of the endoplasmic reticulum stress response
These multiprotein complexes play a pivotal role in orchestrating the inflammatory response by enabling caspase-1dependent activation of the potent pro-inflammatory cytokines interleukin-1 (IL-1) and interleukin-18 (IL-18) upon detection of cellular danger signals (233)
