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Circulating fibroblast growth factor 21 (FGF21) is also implicated in glucagon-induced energy expenditure, as mice lacking FGF21 are protected from this effect [62]

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Any dysfunction in shelterin components can lead to telomere uncapping, exposing telomeres to degradation, recombination, and chromosomal end-to-end fusions, inducing genomic instability potentially resulting in cellular senescence (Sfeir and de Lange, 2012)

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