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Rarely of Clinical Significance Asked to comment, session moderator Lloyd Paul Aiello, MD, PhD, professor of ophthalmology and director of the Beetham Eye Institute at Harvard Medical School, Boston, Massachusetts, told Medscape Medical News that the early worsening of retinopathy with rapid A1c reduction has been seen more often in people with type 1 diabetes than T2D, and that very rarely is it of clinical significance

You can't see this degradationcloudy solutions and foam are late-stage indicators, but peptide bonds start breaking the moment reconstitution temperature exceeds 8C or mechanical stress exceeds the molecule's tolerance threshold

It could be the squeezing of the heart muscle that pumps blood throughout the body

doi: 10.1016/s0014-2999(99)00486-0