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Preventive cardiologist Neha Pagidipati, MD (Duke University School of Medicine, Durham, NC), called SOUL an important clinical trial because it confirms the cardiovascular benefits of oral semaglutide hinted at in PIONEER-6, giving clinicians and patients confidence that the drug works as well as the injectable formulation

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Flexibility is more useful than rigid rules: Appetite and tolerance can change from day to day, so having adaptable options and adjusting portions as needed is often more sustainable than following a strict routine