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Exposure to elevated levels of ROS can lead to cancer cell resistance by the activation of redox-sensitive transcription factors such as NF-B, nuclear factor (erythroid-derived 2)-like factor 2 (Nrf2), c-Jun, and HIF-1 [55]
Currently, 30 drugs are in Phase III trials, 73 are in Phase II, and 82 are in Phase I
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A dominant-negative Gs (DNGs) was generated 3 by introducing eight mutations: S54N, G226A, E268A, N271K, K274D, R280K, T284D, and I285T
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