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Using several hormones in low doses and incorporating lifestyle interventions might maximize the clinical effect while minimizing the side effects. Clearly, many patients would find daily injections of hormones preferable to undergoing bariatric surgery, even if these injections would need to be continued in the long-term to keep the weight off

Nothing worked until GLP-1

Pharmacokinetics: Long acting (half life: ~1 week ) Ozempic & Wegovy : subcutaneous pen injections weekly a more favorable option for some patients compared to daily injections of short acting analogs semaglutide has a high bioavailability of ~89% when injected s.c

Thus, control of autophagy may become a new direction