is tirzepatide better than semaglutide for weight loss vs Tirzepatide: Which Loss? Why You Might Tolerate One

Semaglutide Phase 3 Results (STEP 1) The Phase 3 STEP 1 trial enrolled 1,961 adults with overweight or obesity (BMI 27 with comorbidities or BMI 30) without diabetes (Wilding 2021, NEJM): 2.4 mg weekly: 14.9% body weight reduction at 68 weeks Placebo arm: 2.4% body weight reduction at 68 weeks Responder rates: 86% of subjects on semaglutide achieved 5% weight reduction

However, this adverse effect did not result in an increase in cardiovascular events in dedicated randomized trials [7,8]

Comparing Efficacy in Clinical Trials When we look at how well these medications work, the best place to turn is clinical trial data

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