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With a DVT, your left leg may show symptoms such as: Heaviness, tenderness, or throbbing of leg Pain that feels like a cramp Skin thats warm to the touch Swelling Veins that look larger than usual Changes in skin color (more red or purple than normal in fair individuals) in severe cases- change in color of skin to blue/black indicating death of tissue due to blockage of blood supply(phlegmasia) If the DVT clot breaks off and moves to your lungs (Pulmonary Embolism), youll notice: Chest pain thats worse when you breathe in Coughing up blood Heartbeat thats faster than normal Passing out Shortness of breath or other problems breathing THROMBOLYSIS Strong clot dissolving medications(thrombolytics) given directly into the vein in patient with extensive DVT CLOT ASPIRATION Using negative pressure pumps to suck out the clot from the veins Helps to avoid thrombolytics or reduce its dose used(thereby reducing its complications) Venous angioplasty and stenting- If a narrowing(stenosis) or block(occlusion) is detected in the major veins draining the leg, then angioplasty and stenting maybe needed to improve the blood flow in the vein and provide rapid symptom improvement

Lars Holtug Siham Imani Jan Mller Mikkelsen Executive Board Jan Mller Mikkelsen, Chief Executive Officer Michael Wolff Jensen, Chief Legal Officer Scott Thomas Smith, Chief Financial Officer Anni Lotte Kirstine Pedersen, Chief Administration Officer External Auditors Deloitte Statsautoriseret Revisionspartnerselskab Weidekampsgade 6 DK-2300 Copenhagen S Statement by Management on the Annual Report The Board of Directors and the Executive Board have today considered and approved the annual report of Ascendis Pharma A/S for the financial year January 1 to December 31, 2025

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