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426 The oxidative hepatic environment in obesity inactivates the STAT1/3 phosphatase TCPTP (T-cell protein tyrosine phosphatase) and increases STAT1 and STAT3 signaling

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However, ALCAR reduced the risk of high-grade sagopilone-induced neuropathy (90)

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To conduct this first pharmacological experiment, effective, high doses of the compounds, validated in preclinical models with metabolic alterations 33,34,35,41,42 , were selected

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