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Human obesity studies were also conducted during pharmaceutical development, but the largest reported placebo-controlled study did not demonstrate a statistically significant weight-loss benefit, and development for obesity was discontinued
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The LEADER and SUSTAIN-6 trials, which followed diabetic patients for 37 years on GLP-1 therapy, documented reduced heart attacks and strokes without accumulation of serious toxicity
Doctors prescribe semaglutide for type 2 diabetes and chronic weight management
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