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Quality of evidence: II-B, Strength of recommendation: 1 Panel level of agreement: In total agreement 96%, in partial agreement 4% The WHC have traditionally been used for diagnosing and grading the severity of clinically overt HE, but they are a subjective tool, with limited interobserver reliability, especially for a grade I classification

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Children on sermorelin will have their growth (height and weight) tracked carefully over time, and bone age X-rays periodically, to see if they are responding in terms of growth velocity

It works by promoting angiogenesis (the formation of new blood vessels) and modulating the nitric oxide system key processes in tissue healing