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To overcome the barriers related to injections, semaglutide has become available in oral form containing an absorption enhancer which facilitates uptake through gastric mucosa [19]

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Findings published in a preprint from a phase I clinical trial on the GLP1glucagon receptor co-agonist NN1177 in adults with overweight or obesity have raised problems with deterioration of glucose tolerance and other safety concerns, despite inducing weight loss, which illustrates the difficulties in getting the agonist balance right during the preclinical development of co-agonist therapies 6,7

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