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This chemosensor is expressed by the pancreatic -cells where its signaling activates Gs proteins and induces the secretion of GLP-1 directly through Epac proteins and indirectly via CREB mediated expression of Psck1, while in -cells mediates insulin release [(3]
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Investigation: CEE, LA, SG, SA, TAE, YG, AT, MV & CA
these reactions usually disappear after discontinuation of therapy
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