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Monotherapy Use of Semaglutide in Patients with Type 2 Diabetes Mellitus In a 30-week double-blind trial (NCT02054897), 388 patients with type 2 diabetes mellitus inadequately controlled with diet and exercise were randomized to semaglutide 0.5 mg or semaglutide 1 mg once weekly or placebo

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In diabetes, high blood sugar leads to excess production of reactive oxygen species (ROS), which consume glutathione as the body tries to neutralize these harmful molecules, depleting its levels