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2.2 Succinate In the gut microbiota, succinate is predominantly synthesized by members of the phylum Bacteroidetes and the phylum Firmicutes (e.g., specific Clostridium species) via carbohydrate fermentation pathways (Dai et al., 2025)
Subsequent research by multiple investigators demonstrated that several reduced metabolites of progesterone and deoxycorticosterone act as positive allosteric modulators of GABA A Rs ( As new ideas emerged from clinical studies by Andrew Herzog in the mid 1980s concerning the possible role of estrogen and progesterone in catamenial epilepsy ( A R
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