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Other GLP-1R/GIPR co-agonists such as Cpd86 (Eli Lilly), ZP-DI-70 (Zealand) and NN9709/MAR709 (Novo Nordisk/Marcadia) have also been designed and tested in preclinical models of obesity and subsequently advanced to clinical trials (Table 1)

They work in a few different ways: Increased insulin secretion and sensitivity: Semaglutide helps the body produce more insulin and use it more efficiently

The beta cells in your pancreas that produce insulin gradually lose function over time