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For comparative SAR studies: identical experimental conditions across MT-1, MT-II, and PT-141 treatment groups are essential for valid potency ratio determinations
The mitochondrial steroidogenic acute regulatory protein (StAR) mediates cholesterol transport to the inner mitochondrial membrane, enabling pregnenolone synthesis by P450scc, a process finely regulated by gonadotropins such as FSH and LH [44, 45]
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10.1016/j.bbrc.2007.08.196 Biochem
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