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Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing
The official reason given is safety, even though these peptides have been used safely for years and are produced by reputable compounding pharmacies
Atrial natriuretic peptide (ANP) is a cardiovascular-derived peptide hormone known for its antiproliferative properties that is considered a potential treatment for CRC [130]
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