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The implementation of aerobic endurance training results in an elevation of shear stress and a chronic enhancement of flow-mediated stimuli, which in turn upregulate the expression of eNOS, increase capillary density, and augment mitochondrial oxidative capabilitytransformations that contribute to improved resting and exercise muscle perfusion as well as metabolic efficiency (76, 77)
Moreover, sustaining deep remission was an independent predictor of better outcomes after adalimumab discontinuation [147]
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