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Patients with the following characteristics often see the strongest improvements: Rheumatoid arthritis Psoriatic arthritis Osteoarthritis of the knees or hips Obesity or insulin resistance Chronic fatigue Long-term steroid use Difficulty losing weight despite trying Who Should Avoid GLP-1

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This is partly because tirzepatide has demonstrated strong efficacy for weight loss and other metabolic effects, outperforming other GLP-1 medications in clinical trials

The most honest answer is that we dont yet have every piece of the puzzle