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Figure 1 3 Holistic account of the mechanism of gutbone axis and molecules involved 3.1 Direct effect of gut factors on bone health 3.1.1 Microbe-derived components in bone homeostasis Intestinal factors act on bone either directly or through immune and endocrine transitions, with the direct role of SCFAs in influencing osteoclasts and osteoblasts being prominent

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Housekeeping genes were selected based on those that were consistent in all analyses across genotypes and diets: Sdha , Eef1g , Gapdh , Hprt , Polr2a , Rpl19 , Oaz1 , Tbp , and Tubb5 for liver tissue and Rpl19 , Ppia , Oaz1 , Eef1g , Sdha , Pol2a , Gusb , Tubb5 , Gapdh , and Hprt for F4/80 + cells

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