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MiR-491-3p was shown to negatively regulate the expression of both IGFBP-2 and the cell cycle effector CDK6, whereas the other miR-491 product, miR-4915p targets EGFR and CDK6, leading to decreased cellular proliferation, invasion, and stem cell propagation [42]

Le Thuc O, Stobbe K, Cansell C, Nahon JL, Blondeau N, Rovre C (2017) Hypothalamic inflammation and Energy Balance Disruptions: spotlight on Chemokines

On the other hand, high blood glucose levels are not a mitigating factor in patients with pancreatic -cell dysfunction, and they are at high risk of developing T2DM (13)