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2015 May 1;47:97-105

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Additionally, along with inducing tissue oxidative stress damage, the release of ROS triggers the aggregation of inflammatory cells and the formulation of inflammatory cytokines, growth factors, and transcription factors related to the pathological process of DN ( NLRP3 inflammasome is a multimeric protein complex that induces physiological and pathological inflammatory responses by sensing pathogens, mediates cell pyroptosis, and is a critical downstream factor of NF-B

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