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12 The substitution of GLP-1 Thr 13 or GIP Ile 7 with Ala obviously decreased their receptor-activating activities 25,26 and the substitution of GIP Ile 7 with Thr decreased its cAMP activity (pEC 50 : 9.769.58;Emax: 9.918.90)
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As a naturally occurring chemical, GHRH derives from the hypothalamus, an area of the brain that coordinates the bodily system (i.e., the endocrine system) responsible for controlling just about every important function needed for internal stability growth, energy, metabolism, and reproduction, as well as responses to injury, stress, and mood.4 5 True to its name, GHRH causes the pituitary gland to release growth hormone
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