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At the same time, regulatory focus on early diabetic retinopathy worsening with GLP-1 RAs and guideline recommendations [84] for closer ophthalmic surveillance in high-risk patients or after treatment intensification might have also increased the numbers for eye screening in semaglutide recipients more than in other comparator groups, particularly in the first treatment year, which is also the median follow-up in many of the included cohorts

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Understanding statistical significance, statistical power, sample size, and why epidemiology uses enormous cohorts [51:45]