In this system, the quality of systematic reviews included RCTs set to be high and downgraded by 5 criteria assessment: (1) risk of bias in individual studies, (2) inconsistency of results between studies, (3) indirectness of evidence, (4) imprecision, and (5) publication bias
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As with all major neurodegenerative disorders, development of disease-modifying therapies has proven challenging for multiple reasons
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