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The US Food and Drug Administration (FDA) has approved an additional indication for the weight loss drug semaglutidemarketed as Wegovy (Novo Nordisk) to reduce the risk of major cardiovascular events such as death, heart attack, or stroke in adults with known heart disease and with either obesity or overweight along with a reduced calorie diet and increased physical activity

Am J Clin Nutr 99:408422

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This discomfort typically results from the medication's formulation pH, tissue distension, or individual sensitivity