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As a modified version of the naturally occurring GLP-1 hormone, semaglutide has a 94% amino acid sequence homology to human GLP-1 but includes strategic modifications that extend its half-life to approximately one week, enabling once-weekly dosing
Deficiency of glutathione puts the cell at risk for oxidative damage
A GST mutant in which four glutamine residues were replaced with asparagine (GST 4QN ) exhibited a glutathione binding affinity similar to that of wild-type GST and could be purified by glutathione affinity chromatography
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