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Orforglipron is the development name for Eli Lilly's investigational oral GLP-1 receptor agonist

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This endothelial dysfunction decreases the potent vasodilator nitric oxide (NO) in endothelial and vascular muscle smooth cells, increases the levels of vasoconstrictors such as endothelin-1 [13], and creates a hypercoagulable state by activating platelet aggregation and inhibiting fibrinolysis [14]

J Neurol Neurosurg Psychiatry 89(10):10881100 Mollan SP et al (2019) The expanding burden of idiopathic intracranial hypertension