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However, substantial heterogeneity among studies was observed, likely attributable to differences in dosage, baseline B12 status, and population characteristics

By binding to its receptor (GLP-1R) expressed in various organs, including pancreatic islets, heart, lungs, and brain stem, GLP-1 activates the cAMP-dependent signal transduction pathway to promote glucose-dependent insulin secretion by -cells and improve nutrient utilization in peripheral organs

We previously measured the incretin sensitivity of pancreatic -cells in 10 subjects with normal glucose tolerance and 19 subjects with type 2 diabetes using a hyperglycemic clamp with the sequential addition of GLP-1 and GIP infusions [11]