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This article explores the scientific evidence, clarifies when B12 supplementation might be associated with anxiety-like symptoms, and provides guidance on safe management aligned with UK clinical practice and NICE recommendations
Genetic and pharmacologic studies in mice support this framework, although receptor specificity and downstream signaling remain areas of active investigation
The GLP-1-RA group was associated with reduction in acetazolamide dosage at M6 (\(\beta\)= 288.15, 95% CI 553.09, 23.22, p = 0.03), which did not withstand the adjustment for weight loss
doi: 10.1093/brain/awaa262
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