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Rather than merely debating compounding categories, regulatory bodies must recognize that without robust oversight and a strict mandate for high-quality clinical evidence, the widespread adoption of these signaling molecules will continue to outpace our clinical understanding of their long-term safety, effectively turning an entire generation of patients into an unregulated experiment

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RYBELSUS is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

In addition, the interconnected and dynamic nature of metabolic, inflammatory and fibrotic aspects of the disease, in response to an intervention, add to the difficulty in identifying clear and precise endpoints