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Robbins TW, Everitt BJ (1992)
Manipulation of brain GLP-1 action clearly alters glucose metabolism and insulin sensitivity but brain GLP-1 receptors are not needed for normal glucose control ( For circulating GLP-1 (or GLP-1 analogs) to act on neurons, it must first cross the blood brain barrier (BBB) to reach the brain interstitial fluid compartment
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