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A recent review summarizes safety gaps and the regulatory context in the FDA context

Circadian regulation of L-cell activity in rats is highly sensitive to disturbances in circadian rhythms, as continuous light conditions eliminate normal changes in GLP-1 and insulin nutrient-induced responses and significantly impair glucose tolerance (19), Moghadam and his team similarly found that basal levels of GLP-1 were higher in rats under dark conditions (56), and sensitivity was highest (74)

Elizabeth Rebello, RPh, MD

While unopened pens require refrigeration between 36F and 46F (2C to 8C), the rules change after first use