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Treatment with the serine protease inhibitor camostat, which inhibits, among other proteases, TMPRSS2, reduced glucose-stimulated GIP secretion in GLUTag cells (34), whereas treatment with the FXa-specific inhibitor rivaroxaban showed no significant difference (Figure 2C)

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This is typically reversible with dose reduction or discontinuation

The slower transit time means stool remains in the colon longer, causing it to become harder and more difficult to pass