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Redox Biol 2020;31:101410 21
However, when administering a lower dose of 2APB, i.e., 1 mg/kg, the protective effect on APAP tolerance was observed only in wild-type mice, for which survival rate was 100% at 60 h post-2APB administration
The latter fact is important as it confirms the potential of IGF-1 DES to improve anabolism even in the setting of poor calorie intake, a function that would make the peptide useful in chronic disease and in individuals who are unable to consume a great deal of calories for a variety of reasons
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