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Additionally, it has been suggested that GIPR agonists and antagonists might target different CNS receptor populations, with evidence showing that acylated peptide GIPR agonists act on GABAergic neurons to further reduce food intake and body weight when combined with GLP-1R agonists in mice 39,40
The serum and ascitic fluid samples were collected from different individuals, with the exception of four serum and ascitic fluid samples, in which the patients were the same
While pharmacological tolerance is not well-established with GLP-1 receptor agonists, patients may experience varying degrees of appetite suppression over time
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