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Again, elevated levels of 8-OHdG have been linked to disease severity in various conditions, including cardiovascular disease (188), chronic periodontitis (189), Huntingtons disease (190), chronic kidney disease (191), and colorectal tumors (192194)
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In CKD, uremic dysbiosis causes a decrease in microbial diversity, favoring the growth of pathogenic microbes that raise levels of compounds such as TMAO
The greater impact on morbidity and mortality of diabetes in patients who develop the condition at a younger age compared to those who develop it later [77]
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