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Ethics declarations Ethics approval and consent to participate The evoke and evoke+ trials are being conducted in accordance with the consensus ethical principles derived from international guidelines including the Declaration of Helsinki and applicable ICH Good Clinical Practice (GCP) Guideline, as well as local laws and regulations

Studies have shown that TGF-1 suppresses GCL expression via the JNKATF3 pathway, leading to GSH depletion and enhanced oxidative stress through increased protein and lipid peroxidation [121]

DATA IDENTIFICATION : Articles were obtained via a MEDLINE search of the term glutathione in conjunction with specific disease states mentioned, and via extensive review of references found in articles identified by computer search

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