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The study also showed favorable modifications in lipid profiles, with reductions in total cholesterol, LDL cholesterol, and triglycerides, and a modest increase in HDL cholesterol
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Repeated injection of cocaine dramatically reduces levels of the methyltransferase DNMT3a, which continues to increase after cocaine withdrawal, i.e., the increase in DNMT3a may be an epigenetic mechanism that is particularly important for the withdrawal phase of addiction 86
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