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Funding This work was supported by the Henan Provincial Breast Cancer Precision Prevention and Control Engineering Research Center (ZC20220050), the Henan Provincial Peoples Hospital23456 Talent Engineering Project (ZC23456026) and the study on the Effect and Mechanism of Macrophage-Derived Exosomes Loaded with Doxorubicin for Targeted Therapy of Triple-Negative Breast Cancer (ZC20220114)
Orforglipron showed stronger effects on blood sugar control, HDL cholesterol, and systolic blood pressure, while semaglutide showed larger effects on total body weight, waist circumference, and LDL cholesterol
Novo Nordisk's phase 3 data showed 22.1% weight loss, positioning it between semaglutide and retatrutide
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