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Systemic and endothelial inflammation contribute to collagen deposition, interstitial fibrosis and therefore atrial and ventricular remodelling as well as vascular stiffening [9, 10]

Short-term L-carnitine intake before physical performance A high-dose supplementation (more than 1000 mg) quite shortly before a sporting activity appears to be a recommendable advice, as circulating L-carnitine is considered to have a vascular, protective effect against oxidative damage on the smallest blood vessels (microcirculation)

2.3 Patient 3 A 25-year-old male with PWS, resulting from a uniparental maternal disomy was seen at our Endocrinology Unit

Supplementation with 5 to 10 grams of BCAAs before or after resistance training can enhance muscle preservation