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Hyperglycemia drives the accumulation of advanced glycation end products AGEs, which activate the RAGE/MAPK signaling axis, thereby inhibiting Col-II synthesis and promoting a catabolic state in chondrocytes (31)
At AgeRejuvenation, we match the peptide to the goal
IGF-1 + Steroids (e.g., Testosterone, Anavar, Trenbolone) A full-spectrum PCT should be implemented: Tamoxifen (Nolvadex) 2040 mg/day for 46 weeks DHEA 100 mg/day ZMT To restore testosterone, improve sleep, and lower estrogenic rebound Combining IGF-1 analogs with suppressive anabolics alters HPTA signaling
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