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In general, ROS signaling in eryptosis is less diverse compared to nucleated cells, since in erythrocytes, ROS mainly mediate PS externalization by modulating Ca 2+ influx, while in nucleated cells, there are multiple signaling pathways downstream of ROS involved in the execution of apoptosis

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All the evidence related to cuproplasia and cuproptosis is derived from retrospective studies, with only the association between reduced copper levels and a higher risk of lung cancer stemming from a meta-analysis of retrospective data

doi: 10.1038/s41556-023-01264-z 57 Escada-RebeloSCristoMIRamalho-SantosJAmaralS