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[8] Finally, peptide name, sequence, HPLC area purity, and matching nominal mass are not interchangeable with a complete material-quality assessment
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19, 20 The latter observation led to a recently completed phase I trial of BSO+L-PAM given with stem cell support in the New Approaches to Neuroblastoma Therapy (NANT) consortium that has safely dose-escalated L-PAM given with BSO to myeloablative L-PAM doses, with the stem cell infusions overcoming the expected hematopoietic toxicity (www.NANT.org
This finding was reversed after 6 months of treatment with acetyl-L-carnitine, though the same pattern was not seen in nitric oxide measurements [178]
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