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5-Amino-1MQ is a substrate-mimetic inhibitor that occupies the nicotinamide binding site, with a reported IC of 1.2 0.1 M (Neelakantan et al., J Med Chem, 2017)
He went on to conclude that even though the presence of senile plaques and neurofibrillary tangles were observed, the plaques are not the cause of senile dementia, but only an accompanying feature of senile involution of the central nervous system [7]
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